User:FajarAdnan/sandbox

UD-ARDGenes- University of Dallas Acute Respiratory Distress Syndrome Research Database of Genes
Acute respiratory distress syndrome (ARDS) is defined as an acute-onset, progressive, hypoxic condition with radiographic bilateral lung infiltration, which develops after several diseases or injuries and is not derived from hydrostatic pulmonary edema. Discriminating between ARDS and other similar diseases is critically important; In parallel with progress in understanding the pathophysiology of ARDS, various humoral factors induced by inflammation, and molecules derived from activated cells or injured tissues have been shown as potential biomarkers that may be applied in clinical practice. This database resource developed by the University of Dallas provides comprehensive curated information on genes with experimentally validated information related to Acute Respiratory Distress Syndrome. Version 1 of the UD-ARDGenes portal provides information on 245 unique genes curated from 10 published studies and comprehensive research articles. The qualifying genes selected for database inclusion are genes believed to be significant in the susceptibility and/or (pathogenesis) progression of ARDS in humans. The following types of metadata are included for each gene entry: the Official Gene Symbol (as approved by the HUGO Gene Nomenclature Committee) and information taken from the NCBI Gene Database: Full Name, Alternate Alias Names, NCBI Gene ID, Cytogenetic location, Position Start, Position End, Reference Sequence, and Gene Function. For genes with relevant variants, each variant ID is listed along with Variant Type, Variant Consequence, and Variant Location, information taken from the dbSNP database. In the human genome reference sequence, GRCh38 was utilized to confirm both gene location and variant location in relation to the reported gene. Additional descriptions of the gene’s relationship to ARDS, based on the biological function provided from the primary source study are included where possible.