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Effect of Exercise as Treatment for Cystic Fibrosis (CF)
Brief Background

Common autosomal genetic disease causing problems in the respiratory and digestive systems. It is caused by a mutation of the Cystic Fibrosis Transmembrane Regulatory (CFTR) gene in the exocrine.

Explanation/Diagnosis of CF

Diagnosis usually occurs during early childhood and two main criteria used to diagnose CF include:


 * Genetic Testing (prenatal or early childhood)


 * Sweat Test (sodium chloride levels)

To help confirm the clinical diagnosis, medical specialists will look for the following symptoms:


 * Chronic cough


 * Trouble breathing


 * Repeated chest infections


 * Poor weight gain


 * Diarrhea/constipation


 * Salty sweat

Treatment

Exercise as treatment for CF patients in conjuction with more traditional treatments has been found to have positive effects, including:


 * Increased exercise capacity


 * Improved cardiorespiratory fitness


 * Improved pulmonary function

Treating CF through the use of medications is one of the more traditional methods to limit or inhibit the symptoms of CF. Azithromycin and tobramycin are two significant antibiotics that are beneficial towards treating CF.


 * Azithromycin (prevents bacteria growth)


 * Tobramycin (inhibits mRNA translation)

However, side effects of these medications can include:


 * Hearing Loss


 * Diarrhea


 * Vomiting

Chest Physiotherapy administered by a parent, partner or physiotherapist following exercise has also been found to be beneficial towards inhibiting the symptoms associated with CF.

Recommendations


 * CF patients should consult their general practitioner before starting an exercise program and from there can create a schedule suited to themself.


 * A minimum of 30 minutes of moderate to high intensity exercise should be performed 3-4 times a week in whatever physical activity the patient feels comfortable with.

Further Reading


 * Cystic Fibrosis Australia