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Needed in many experimental fields, fluorescence sensor arrays was proceed for better number of analytes. Many of such arrays were used in both DNA and RNA hybridization assays, detecting antigens and antibodies along with new drug discoveries. Fluorescence sensor arrays also extended in studying proteomes to construt extended maps of protein-protein interactions.

The comparative analysis of fluorescence detection was based on three main properties: 1. Insensitivity to instrumental factors. 2. Insensitivity to the concentration of sensor molecules. 3. Insensitivity to environmental factors like fluorescence.

The major application of such technique is to provide a response to analyte binding by changing the rotational mobility of fluorescent reporter.

Source Cited:

Zhu, H. and Snyder, M. (2003) Protein chip technology. Curr. Opin. Chem. Biol. 7, 55–63 2 Venkatasubbarao, S. (2004) Microarrays - status and prospects. Trends Biotechnol. 22, 630–637 3 Templin, M.F. et al. (2002) Protein microarray technology. Trends Biotechnol. 20, 160–166