Talk:Radiation Oncology/Breast/Partial breast irradiation

The following should be added to

Meta-Analysis

 * Heraklion University, Greece; 2010 PMID 20210799 -- "Partial Breast Irradiation or Whole Breast Radiotherapy for Early Breast Cancer: A Meta-Analysis of Randomized Controlled Trials." (Valachis A, Breast J. 2010 Feb 23. [Epub ahead of print])
 * Meta-analysis. 3 trials with 1,140 patients.
 * Outcome: No difference in OS (OR 0.9, NS), DM (OR 0.7, NS), or SCV recurrences (OR 1.4, NS). However, PBI increased risk of local recurrence (OR 2.1, SS), and axillary recurrence (OR 3.4, SS) compared with whole breast RT
 * Conclusion: PBI doesn't jeopardize survival but issue of locoregional recurrence needs to be addressed
 * Letter to editor (Polgar C, PMID 20127229): Inappropriate to include the 2 "old" British trials using inadequate patient selections criteria


 * Aarhus, Denmark; 2009 PMID 18783840 -- "Accelerated partial breast irradiation as part of breast conserving therapy of early breast carcinoma: A systematic review." (Offerssen BV, Radiother Oncol. 2009 Jan;90(1):1-13. Epub 2008 Sep 8.)

NEW material

A meta-analysis of randomised trials of partial breast irradiation (PBI) vs. whole breast irradiation (WBI) as part of breast conserving therapy (more than 4000 patients) demonstrated a reduction in non-breast-cancer and overall mortality. Full text and Audio Slides