Talk:Radiation Oncology/Breast/DCIS/Van Nuys

VNPI
The article does not mention that the classification system was developed retrospectively and has not been validated in prospective studies nor in different retrospective studies of other institutions. Prospective randomized trials (Wong 2006, JCO) reported in the DFCI study of women with DCIS and > 1 cm margins and low grade (1-2) disease in the observation arm was stopped due to meeting early stopping rules for excessive failures. This is the only trial that looked at the general critera of the VNPI with the hope of identifying need for treatment post lumpectomy. Wong looked at mammography size, rather than pathologic size in stratifying results.