Talk:Proteomics/Proteomics and Drug Discovery/Structure-Based Drug Design

History of Structural methods
The initial pargraph makes it sound as if no model building work was done at all in the early 80's due to a lack of computing power. That's misleading. It was just much more expensive, less automated and at a less advanced stage. Evans and Sutherland's machines were being used for enzyme models and to guide choices in synthesis of variant inhibitors. JamesCrook (talk) 11:22, 31 October 2010 (UTC)

Enzyme Target?
The following phrase needs to be changed: sildenafil citrate (Viagra), which targets the catalytic subunit of NADPH (Jeremy);

NADPH is a small molecule that provides reductive power for synthetic processes. What is the exact enzyme targeted by viagra?