Talk:Human Physiology/Genetics and inheritance

I added an inheritance table; I found it from a Merlot site. I moved your definitions down before your review questions, Kevin had a format he recomended. Dorothy

Subject: Genetics & Ineritance
Message no. 43 Author: Dorothy Duncan Date: Monday, July 31, 2006 9:40am Angie, Melissa, & Tori I have put a few images on your chapter, just an idea, maybe you have some others that you would prefer, I can help with that. Also, you should put your References down, possibly as your last subject; you can look at at my ch. Pregnancy & Birth to get some ideas.

Kevin, I went to the discussion page, I can't figure out how to leave this goup a message there.

Thanks, Dorothy

I thought this was good info. You have talked alot about the two types of hemophilia but you never say what factor is missing. Give some examples of whether a women carries this gene or the man will pass the gene to his off spring. Also when I took this class before kevin talked about queen victoia having hemophilia. I think it is always easier to learn when you can relate the concepts to an actual situation. Andrea Keller "Patients with hemophilia A lack the blood clotting protein, factor VIII, and those with hemophilia B lack factor IX. There are about 20,000 hemophilia patients in the United States. Each year, about 400 babies are born with this disorder. Approximately 85% have hemophilia A and the remainder has hemophilia B." http://www.medceu.com/tests/hemophilia.htm

It is generally considered unsightly to write a page in all capital letters. I recommend that somebody fix this to use proper capitalization. --Whiteknight (talk) (projects) 17:57, 21 July 2006 (UTC)

Definitions list
In response to Whiteknight I changed your page to non-capitals. I also formatted your definitions with a definition list format (you will see how to do it when you edit your page). If you decide to do a list of definitions you mights want to search google with "define: genetics" and define: inheritance and so forth. That way you can look at several definitions while deciding upon your own. Thanks for jumping right in--I look forward to seeing additional content soon! Provophys 19:39, 21 July 2006 (UTC)

Thanks for fixing the chapter. my keyboard was having issues number lock and caps were permanently stuck on at random times. I finally broke down and spent the 10 dollars to get a new keyboard. If I would have known how cheap they were I would have bought one awhile ago. Melissasmith 02:13, 28 July 2006 (UTC)


 * That's a funny story!

Big subject!
I lectured on genetics to my microbiology class yesterday and was reminded what a big, complex topic genetics is. I like your approach so far. Just keep in mind who your audience is--introductory physiology students with an interest in medicine--and I think you will be able to wade through everything and glean what is most applicable. Do you think you should talk about replication? Transcription and translation? Mitosis vs meiosis (probably not)? Mendelian genetics? Mutations? I think using genetic diseases to highlight and explain principles might be useful. Treatment for inherited diseases varies quite a bit--for some inherited diseases nothing can be done, for others (such as hemophilia) a functioning protein can be given by injection to compensate for the mutated gene, while for others (cystic fibrosis) gene therapy offers great promises.

I'll be watching with interest! ~Kevin Provophys 20:30, 27 July 2006 (UTC)

Thanks for the advice. I have been looking up information on genetic diseases and there is A LOT! I am going to go through it all and try to find the best info to put into the chapter. If you have any really good web sites you could tell me about I would appreciate it. Thanks again.Melissasmith 02:12, 28 July 2006 (UTC)

Images
I've found some images that might be of use in this chapter. Feel free to add them if you think they are appropriate:


 * [[Image:Autorecessive-3.png]]
 * [[Image:DNA animation.gif]]
 * [[Image:Autorecesiva.png]] (in spanish)
 * [[Image:Ccl7 code.GIF]]
 * [[Image:Chromatin chromosom.png]]
 * [[Image:Copiadna.JPG]]
 * [[Image:Dna-split.png]]

And there are many others to be found at: commons:Category:Genetics. Let me know if you need any help. --Whiteknight (talk) (projects) 14:28, 7 August 2006 (UTC)

Review
This is a very intense area of study and heavy chapter but it looks very good. I like the table of contents, I think that it is arranged very well and covers the most needed information.I thought mabey there couold be more of an introduction to the chapter that could really grab the reader or give more of an overview to what is going to be discussed in the chapter and is there any more information to add to the gene section?I love the timeline of notable discoveries and find the inheritance section and information to be interesting. The last thing that I would suggest is that mabey the smaller sections like polygenic traits, be subsectioned or added somewhere else. There are a few that seem too small to have their own section unless you find more information to add. That way you can condense a little or add to fill those little sections. Good work and good luck, thanks!--JamBam 00:54, 18 August 2006 (UTC)

Thoughts on what to include or exclude
In thinking about what is of greatest value to a beginning physiology student, there are several things that come to my mind (of course, this list would be different for others). I think an introduction of genetics should include the basic structure of DNA, a brief history of the study of inheritance, and explanations of chromosomes and genes. Maybe some treatment of the nature vs nurture debate, and some examples showing effects of both. I think it helpful to explain the processes of replication, transcription, and translation so people understand the basics of what DNA is used for. An explanation of inheritance, focusing on simple dominant/recessive traits first, is good, then you can discuss variations to that model with polygenic traits, sex-linked traits, etc. A discussion of mutations followed by a discussion of several genetic disorders (such as cystic fibrosis, hemophilia, etc). Discussion of current and possible future treatments for genetic diseases, and maybe ethical issues that branch off of that. Maybe discussing implications of completing the map of the human genome. I would perhaps exclude, or at least move to a less-prominent position, the section entitled "Areas of Genetics."

I relegated several headings to subheadings under "Exceptions to Simple Inheritance." I'm not sure about that section. All those exceptions are interesting, but perhaps we should focus on the norm and not get too caught up in the exceptions. Also, I would move multifactorial inheritance directly after unifactorial inheritance, and expand upon sex-linked inheritance. I would recommend checking a few beginning biology books or a few anatomy/phys books to see what they include.

For your introductory story, you mentioned a narrative of Mendel. That would be interesting, but I think it may flow better with the other chapters if you give a medical situation of someone with an inherited disorder. Discuss it as a group and make the decision.

Finally, if you could tie in homeostasis. . . turning genes on and off is the body's ultimate regulatory switch over several processes (e.g. embryonic development, puberty, aging, etc).

Those are my thoughts for today. I'll be anxious to see what you come up with. Keep up the good work! Provophys 22:09, 21 August 2006 (UTC)

Review
This is a large complex subject. I like how you have aranged it and what you have focused on. There is one part that I was confused on....The mutant gene section is confusing. It said that “a mutant gene can be indifferent because the mutation is no different than the original.” If it isn’t different than the original how is it mutate. Good luck. --Clareceglanville 22:24, 21 August 2006 (UTC)

cell cycles
the uniqueness of the events of cell cycle in human Adna hassan (discuss • contribs) 18:13, 14 January 2019 (UTC)