Structural Biochemistry/MAOIs

MAOIs stands for monoamine oxidase inhibitors. They are antidepressant drugs that work by preventing the enzyme monoamine oxidase from metabolizing neurotransmitters. These neurotransmitters include serotonin, norepenephrine, and dopamine. Because these neurotransmitters are not metabolized, they remain in the brain and this helps elevate mood. It is also thought that the drug supports nerve cells within the brain from glutamate sensitivity. This prevents glutamate from stimulating areas of the brain that are responsible for depression and anxiety.