Radiation Oncology/Toxicity/Kidney

Kidney RT Tolerance

Spare 2/3 of one kidney.


 * Willett et al, 1986 - PMID 3759586 &mdash; "Renal complications secondary to radiation treatment of upper abdominal malignancies." Willett CG et al. Int J Radiat Oncol Biol Phys. 1986 Sep;12(9):1601-4.
 * Retrospective. Looked at 86 pts who received > 26 Gy to 50% of one kidney. Minimum 1 yr f/u. Creatinine clearance based on the Cockcroft formula.
 * Mean % decrease in GFR was 10% if only 50% of a kidney irradiated and 24% if 90-100% of one kidney was irradiated.