Radiation Oncology/Toxicity/Fertility

Fertility


 * Also please see Toxicity/Ovary
 * Also please see Toxicity/Testis
 * Also please see Toxicity/Pituitary
 * Also please see Toxicity/Pelvis (general information)


 * Childhood Cancer Survivor Study (1970-1986)
 * 2009 PMID 19364965 -- "Fertility of female survivors of childhood cancer: a report from the childhood cancer survivor study." (Green DM, J Clin Oncol. 2009 Jun 1;27(16):2677-85. Epub 2009 Apr 13.)
 * Retrospective. 5,149 femarle CCCS 5-year survivors not surgically sterile and cohort of 1,441 randomly selected female siblings
 * Outcome: RR for ever being pregnant 0.81 (SS)
 * Negative predictors: hypothalamic/pituitary RT dose >=30 Gy (RR 0.61), ovarian/uterine RT dose >5 Gy (RR 0.56) or RT dose >10 Gy (RR 0.18), treatment with lomustine or cyclophosphamide, or summed alkylating agent dose (AAD) 3-4
 * Conclusion: Fertility decreased among female pediatric cancer survivors