Radiation Oncology/Toxicity/Bone marrow

See also: Radiation Oncology/IMRT/Pelvis
 * Also please see Toxicity/Pelvis

Bone marrow distribution
Distribution of Bone Marrow


 * 1961: (London) - PMID 13726497 &mdash; "The distribution of active bone marrow in the adult." Ellis RE et al. Phys Med Biol. 1961 Jan;5:255-8.
 * By weighing cadaveric bones.

Cervical Cancer

 * UC San Diego
 * 2011 PMID 20400238 -- "Normal tissue complication probability modeling of acute hematologic toxicity in cervical cancer patients treated with chemoradiotherapy." (Rose BS, Int J Radiat Oncol Biol Phys. 2011 Mar 1;79(3):800-7. Epub 2010 Apr 17.)
 * Retrospective. 81 patients treated with concurrent chemo-RT for cervical cancer. DVHs of bone marrow in pelvic field evaluated
 * Outcome: V10 <95% and V20 <76% correlated with lower acute G3+ hematologic toxicity. V10 (25% vs 69%, SS) and V20 (22% vs 58%, SS)
 * Conclusion: Acute hematologic toxicity increases with increasing pelvic bone marrow volume irradiated