Radiation Oncology/Sebaceous

Sebaceous Carcinoma

Background

 * Very rare
 * Commonly presents as a gradually enlarging, firm nodule
 * >70% located in the head & neck region, especially periorbital
 * Spread is to regional lymph nodes

Treatment
Treatment is largely surgical via wide excision or Mohs. Radiation or topical therapies are sometimes used.


 * SEER / Yale (1973-2004) PMID 18988294 -- "A retrospective review of 1349 cases of sebaceous carcinoma." (Dasgupta T, Cancer. 2009 Jan 1;115(1):158-65.)
 * 1349 pts. Review of SEER database from 1973-2004. Median age 73 yrs. 5-yr and 10-yr relative survival rate (age-matched): 91.9% and 79.2%. Cancer was cause of death in 31%.