Radiation Oncology/Sarcoma/Hemangioendothelioma

Hemangioendothelioma


 * Rare tumor
 * Intermediate-grade malignant tumors, clinically behaving between benign hemangioma and malignant angiosarcoma. Some have rather benign course while others show much more malignant progression
 * Typically occur in adults with roughly equal sex distribution
 * Most common location is soft tissues, but have been described essentially anywhere in the body
 * Symptoms depend upon location of the primary tumor
 * Most common histologic type is epithelioid hmangioendothelioma (EHE)
 * For isolated tumors, curative resection with negative margin should be performed
 * Role of adjuvant RT is unclear, but is often considered
 * Most common metastatic sites are lungs, liver, lymph nodes and bone
 * Effectiveness of chemotherapy is unclear
 * Most studies are small single institution series