Radiation Oncology/Rectum/Review

Rectal Cancer Review


 * Surgical margin
 * R0 typically defined as >1 mm
 * Prognostic impact on LR and OS
 * Neoadjuvant chemo-RT
 * Superior over adjuvant chemo-RT: German Rectal Trial
 * Superior over neoadjuvant RT alone: EORTC 22921 and FFCD 9203
 * No difference in OS, 5-year ~65%
 * Significant benefit for LR 16-17% -> 8-9%
 * R0 ~90%; ypCR 15-20%