Radiation Oncology/Radiobiology/Radiobiology and lung

RADIATION INJURY IN LUNG:


 * Pneumocytes type II —> main target of radiation
 * Earliest response to radiation
 * ==> decrease in lamellar bodies
 * ==> increase in alveolar surfactant
 * By 18–63 weeks
 * Degeneration & sloughing into alveolar spaces
 * Inflammatory cytokines
 * IL-1α/β
 * TGF-β
 * PDGF
 * Collagen and fibronectin genes