Radiation Oncology/RTOG Trials/9019

RTOG 90-19 (PROSTATE)
 * Link to textbook
 * This is a SWOG-8794 Study (INT-0086, CALGB-9493, EST-9887)
 * Title: A Phase III Study of the Treatment of Pathologic Stage C Carcinoma of the Prostate With Adjuvant Radiotherapy
 * Objectives:
 * (1) To compare the disease-free survival rates in completely resected patients with pathologic stage C (T3N0M0) carcinoma of the prostate assigned to be treated with adjuvant external beam radiotherapy to that in patients assigned to receive no adjuvant therapy
 * (2) To assess the qualitative and quantitative toxicities of patients with pathologic stage C (T3N0M0) carcinoma of the prostate when treated with external beam radiotherapy.
 * Protocol:
 * Arm 1: Radical Prostatectomy
 * Arm 2: Radical Prostatectomy + 60-64 Gy EBRT
 * Eligibility: Status Post RP, +ECE or +SVI or +SM, N0M0
 * Activation: August 15, 1988 (RTOG Activation: April 20, 1992)
 * Closed: January 1, 1997
 * Publications:
 * 2007 PMID 17538167 -- "Predominant treatment failure in postprostatectomy patients is local: analysis of patterns of treatment failure in SWOG 8794." (Swanson GP, J Clin Oncol. 2007 Jun 1;25(16):2225-9.) Conclusion : Failure in high risk patients predominately local; adjuvant RT reduces risk of failure
 * 2006 PMID 17105795 &mdash; "Adjuvant radiotherapy for pathologically advanced prostate cancer: a randomized clinical trial." (Thompson IM Jr et al. JAMA. 2006 Nov 15;296(19):2329-35.) Conclusion: Adjuvant radiotherapy resulted in significantly reduced risk of PSA relapse and disease recurrence, although the improvements in metastasis-free survival and overall survival were not statistically significant.
 * 2005 ASTRO Abstract Plenary #1, 2005 Webcast - "Phase III Randomized Study of Adjuvant Radiation Therapy versus Observation in Patients with Pathologic T3 Prostate Cancer (SWOG 8794)" Swanson GP et al. IJROBP Volume 63, Supplement 1, 1 October 2005, Page S1.
 * 1994 No Abstract -- "An opportunity to determine optimal treatment of pT3 prostate cancer: the window may be closing." (Thompson IM, Urology 1994). Review
 * 1992 -- "Adjuvant Radiotherapy Following Radical Prostatectomy for Pathologic Stage C Adenocarcinoma of the Prostate:  Initial Evaluation of Toxicity."  I Thompson, ED Crawford, G Miller, J Paradelo, B Blumenstein, M Wolf, C Moinpour, K Hayden. American Society of Clinical Oncology 11:212 (#663), 1992.