Radiation Oncology/RTOG Trials/7605

RTOG 76-05 (LIVER)
 * Title: Pilot Study of Radiotherapy for Palliation of Symptomatic Hepatic Metastases
 * Objective:
 * I. Evaluate the frequency and duration of symptom relief, frequency and duration of normalization of (a) liver tests and (b) of abnormal liver scans, as a function of dose schedules, varying fraction size and overall time.
 * II. Evaluate the above responses according to site and histopathology of the primary.
 * III. Evaluate the above objectives with respect to survival times.
 * IV. Evaluate, via histopathologic correlation, the frequency of radiation hepatitis as a function of dose schedule and concomitant chemotherapy.
 * Protocol: RT for patients with solitary vs. multiple mets
 * Eligibility: hepatic metastases documented by liver scan
 * Enrolled:
 * Conclusion:
 * PMID 6168623 -- The palliation of hepatic metastases: results of the Radiation Therapy Oncology Group pilot study. (1981 Borgelt BB, Int J Radiat Oncol Biol Phys. 1981 May;7(5):587-91.)
 * Publications:
 * PMID 2180867 -- Accelerated fractionation radiation therapy for liver metastases: selection of an optimal patient population for the evaluation of late hepatic injury in RTOG studies. (1990 Leibel SA, Int J Radiat Oncol Biol Phys. 1990 Mar;18(3):523-8.)