Radiation Oncology/Palliation/Lung metastases

Lung Metastases


 * Colorado; 2009 PMID 19255320 -- "Multi-institutional phase I/II trial of stereotactic body radiation therapy for lung metastases." (Rusthoven KE, J Clin Oncol. 2009 Apr 1;27(10):1579-84. Epub 2009 Mar 2.)
 * Phase I/II. 38 patients, 63 lesions, 1-3 lesions. 71% prior chemo. Median GTV 4.2 ml (0.2-52.3 ml). SBRT 60/3 @ 20 Gy/fx. Median F/U 15 months
 * Outcome: Actuarial LC 1-year 100%, 2-years 96%. Median OS 19 months
 * Toxicity: Grade 3 toxicity 8% (3/38), symptomatic pneumonitis 3% (1/38)
 * Conclusion: High-dose SBRT safe and effective