Radiation Oncology/GOG

Gynecologic Oncology Group (GOG)


 * Gynecologic Oncology Group website
 * Wikipedia GOG page
 * Wikibooks Endometrial cancer page

88XX-02XX

 * GOG 0230-C - Uterus/Carcinosarcoma - A Phase II Evaluation of GLEEVEC (NCI-Supplied Agent: STI571 [Imatinib Mesylate], IND#61135, NSC#716051) in the Treatment of Recurrent or Persistent Carcinosarcoma of the Uterus


 * GOG 0227-C - Cervix - A Phase II Evaluation of Bevacizumab (rhuMAB VEGF) (NSC# 704865 IND#7921) in the Treatment of Persistent or Recurrent Squamous Cell Carcinoma of the Cervix


 * GOG 0210 - Endometrium - A Molecular Staging Study of Endometrial Carcinoma


 * GOG 0209 - Endometrium - Randomized Phase III Trial of Doxorubicin/Cisplatin/Paclitaxel and G-CSF Versus Carboplatin/Paclitaxel in Patients with Stage III & IV or Recurrent Endometrial Cancer


 * GOG 0199 - Ovary - Prospective Study of Risk-Reducing Salpingo-Oophorectomy and Longitudinal CA-125 Screening Among Women at Increased Risk of Ovarian Cancer


 * GOG 0184 - Endometrium - A Randomized Phase III Study of Tumor Volume directed Pelvic Plus or Minus Para-Aortic Irradiation Followed by Cisplatin and Doxorubicin or Cisplatin, Doxorubicin and Paclitaxel for Advanced Endometrial Carcinoma


 * GOG 0182 - Ovary - A Phase III Randomized Trial of Paclitaxel and Carboplatin Versus Triplet or Sequential Doublet Combinations in Patients With Epithelial Ovarian or Primary Carcinoma.


 * GOG 0181-B - Endometrium - A Phase II Evaluation of Trastuzumab (MoAb HER 2) in Patients with Recurrent or Advanced Endometrial Carcinoma


 * GOG 9908 - Endometrium - Sequential chemotherapy and irradiation in advanced stage endometrial cancer: A Gynecologic Oncology Group phase I trial of doxorubicin-cisplatin followed by whole abdomen irradiation.
 * PMID 19135232 (2009)


 * GOG 9907 - Endometrium - Phase I trial of the treatment of high-risk endometrial cancer with concurrent weekly paclitaxel and cisplatin and whole abdominal radiation therapy
 * PMID 18962846 (2009)


 * GOG 9804 - Cervix - Phase I/II study of extended field radiation therapy with concomitant paclitaxel and cisplatin chemotherapy in patients with cervical carcinoma metastatic to the para-aortic lymph nodes
 * PMID 19010522 (2009)


 * GOG 9404 - Ovary - P53 MUTATION AND C-ERB B-2 EXRESSION IN ADVANCED STAGE EPITHELIAL OVARIAN CARCINOMA AND CORRELATION WITH PROGNOSTIC FACTORS AND TREATMENT OUTCOME


 * GOG 9303 - Ovary - CISPLATIN-DNA ADDUCTS IN OVARIAN CANCER AS A PREDICTOR OF RESPONSE TO PLATINUM-BASED CHEMOTHERAPY


 * GOG 9203 - Ovary - Phase I trial of paclitaxel and etoposide for recurrent ovarian carcinoma
 * PMID 11202808 (2000)


 * GOG 9001 (1990-92) - Endometrial - A phase I study of weekly cisplatin and whole abdominal radiation for the treatment of stage III and IV endometrial carcinoma: a Gynecologic Oncology Group pilot study.
 * PMID 8946862 (1996)


 * GOG 8809 - Ovary - FLOW CYTOMETRICALLY DETERMINED TUMOR DNA CONTENT IN OVARIAN TUMOR OF LOW MALIGANT POTENTIAL

201-300

 * GOG 258 (ongoing) - Endometrium - A Randomized Phase III Trial of Cisplatin and Tumor Volume Directed Irradiation Followed by Carboplatin and Paclitaxel vs. Carboplatin and Paclitaxel for Optimally Debulked, Advanced Endometrial Carcinoma


 * GOG 206 (ongoing, 2003-) - Cervix - Stage IB1. Sentinal lymph node biopsy.


 * GOG 205 (2005-2009) - Vulva - Phase II trial of radiation therapy and weekly cisplatin chemotherapy for the treatment of locally-advanced squamous cell carcinoma of the vulva. Unresectable, T3-T4 any N. RT + weekly cisplatin followed by resection of residual tumor.


 * GOG 204 - Cervix - Advanced. Rand to 4 cisplatin doublets (taxol, vinorelbine, gemcitabine, or topotecan)
 * PMID 19720909 (2009)

151-200

 * GOG 191 - Cervix - Stage III. Chemo-RT +/- EPO
 * chapter link
 * PMID 18037478 (2008): Stopped prematurely due to concerns about thromboembolism


 * GOG 185 - Vulva - Phase III randomized study of adjuvant radiation treatment versus radiation and chemotherapy (cisplatin) in patients with vulvar cancer and involved nodes


 * GOG 184 - Endometrium - A randomized phase III trial in advanced endometrial carcinoma of surgery and volume directed radiation followed by cisplatin and doxorubicin or with or without paclitaxel
 * PMID 19108877 (2009)


 * GOG 0177 - Endometrium - Phase III trial of doxorubicin plus cisplatin with or without paclitaxel plus filgrastim in advanced endometrial carcinoma
 * PMID 15169803 (2004), HER2-neu: PMID 17945336 (2008)


 * GOG 175 - Ovary - A Randomized Phase III Trial Of IV Carboplatin (AUC 6) and Paclitaxel 175 MG/M2 Q 21 Days X 3 Courses Plus Low-Dose Paclitaxel 40 MG/M2 Weekly VS. Carboplatin (AUC 6) and Paclitaxel 175MG/M2 Q21 Days X 3 Courses in Patients With Early Stage Ovarian Cancer


 * GOG 173 - Vulva - Sentinal lymph node mapping (Stage I-II)
 * ASCO 2009 Abstract #5505


 * GOG 172 - Ovary - A PHASE III RANDOMIZED TRIAL OF INTRAVENOUS PACLITAXEL AND CISPLATIN VERSUS INTRAVENOUS PACLITAXEL, INTRAPERITONEAL CISPLATIN AND INTRAPERITONEAL PACLITAXEL IN PATEINTS WITH OPTIMAL STAGE III EPITHELIAL OVARIAN CARCINOMA OR PRIMARY PERITONEAL CA


 * GOG 171 - Cervix - Expression of the MN Protein in Atypical Glandular Cells of Undetermined Significance (AGUS or AGCUS) as a Potential Diagnostic Biomarker of Cervical Dysplasia/Neoplasia


 * GOG 165 - Cervix - A RANDOMIZED COMPARISON of RADIATION PLUS WEEKLY CISPLATIN VS RADIATION PLUS PVI (PROTECTED VENOUS INFUSION) 5-FU IN PATIENTS WITH STAGE II-B, III-B, AND IVA CARCINOMA OF THE CERVIX
 * PMID 16230678 (2005)


 * GOG 163 - Endometrium - A Randomized Study of Doxorubicin + Cisplatin vs. Doxorubicin + 24 HOUR Paclitaxel + G-CSF In Patients With Primary Stage III & IV Or Recurrent Endometrial Carcinoma


 * GOG 161 - Uterus/Mixed Mesodermal - A Phase III Trial of Ifosfamide vs Ifosfamide Plus Paclitaxel in Patients with Advanced, Persistent or Recurrent Carcinosarcoma (Mixed Mesodermal Tumor) of the Uterus
 * PMID 17290061 (2007)


 * GOG 159 - Endometrium - A PHASE II STUDY OF GOSERELIN ACETATE (ZOLADEX) IN RECURRENT OR PERSISTENT ENDOMETRIAL CANCER


 * GOG 158 - Ovary - A Phase III Randomized Study Of Cisplatin & Paclitaxel (24 Hour Infusion) Versus Carboplatin & Paclitaxel (3-Hour Infusion) In Optimal Stage III Epithelial Ovarian Carcinoma


 * GOG 157 - Ovary - A Randomized Phase III Trial Of Carboplatin (AUC 7.5) & Paclitaxel 175 Mg/M Q 21D X 3 Courses vs. Same Regimen X 6 Courses In Patients With Selected Stage IC And II II (A,B,C) And Selected IA AND IB Ovarian Cancer.


 * GOG 156 - Endometrium - Stage IB and IIB, Surgery + Pelvic RT vs. Surgery + Adriamycin/Cisplatin
 * Closed due to nonaccrual


 * GOG 154 - Cervix - HUMAN IMMUNODEFICIENCY VIRUS (HIV) TESTING IN PATIENTS WITH INVASIVE CERVICAL CANCER

101-150

 * GOG 150 - Uterus/Carcinosarcoma - adjuvant WAI vs. CIM. No statistically significant advantage of one over the other. Pelvic recurrences reduced with RT
 * PMID 17822748 (2007)


 * GOG 149 - Cervix - A RANDOMIZED STUDY OF CISPLATIN PLUS IFOSFAMIDE & MESNA VS CISPLATIN, BLEOMYCIN,IFOSFAMIDE & MESNA IN STAGE IVB RECURRENT OR PERSISTENT SQUAMOUS CELL CARCINOMA OF THE CERVIX


 * GOG 146-H - Ovary - EVALUATION OF PYRAZOLOACRIDINE (PZA) IN RECURRENT,PLATINUM SENSITIVE OVARIAN CANCER


 * GOG 146-F - Ovary - EVALUATION OF 24-HOUR CONTINUOUS INFUSION OF TOPOTECAN IN RECURRENT AND PLATINUM-SENSITIVE OR METASTATIC OVARIAN CANCER


 * GOG 146D - Ovary - EVALUATION OF PYRAZOLOACRIDINE (PZA) IN RECURRENT PLATINUM SENSITIVE OVARIAN CANCER


 * GOG 145 - Vulva - Randomized study of adjuvant treatment including radiation therapy and chemotherapy in patients with vulvar cancer


 * GOG 141 - Cervix - Neoadjuvant chemo followed by rad hyst vs rad hyst alone. Closed early.


 * GOG 0136 - Other - Acquisition of Human Gynecologic Specimens and Serum to be Used in Studying the Causes, Diagnosis, Prevention and Treatment of Cancer


 * GOG 132 - Ovary - Phase III randomized study of cisplatin versus paclitaxel versus cisplatin and paclitaxel in patients with suboptimal stage III or IV ovarian cancer
 * PMID 10623700 (2000)


 * GOG 129-G - Endometrium - EVALUATION OF 9-CIS RETINOIC ACID(9-CRA, NSC#659722) IN THE TREATMENT OF REFURRENT OR PERSISTENT ENDOMETRIAL CARCINOMA PREVIOUSLY TREATED BY CHEMOTHERAPY


 * GOG 129-E - Endometrium - EVALUATION OF DACTINOMYCIN (COSMEGEN) IN THE TREATMENT OF RECURRENT OR PERSISTENT ENDOMETRIAL CARCINOMA.


 * GOG 127-J - Cervix - EVALUATION OF 9-CIS RETINOIC ACID(9-CRA.NSC#659722) IN PERSISTENT OR RECURRENT SQUAMOUS CELL CARCINOMA OF THE CERVIX PREVIOUSLY TREATED BY CHEMOTHERAPY


 * GOG 127-C - Cervix - EVALUATION OF CISPLATIN AND PENTOXIFYLLIN IN ADVANCED OR RECURRENT SQUAMOUS CELL CARCINOMA OF THE CERVIX


 * GOG 126-M - Ovary - Phase II Evaluation of Epothilone-B (BMS 247550) (IND #59699 NSC #710428) in the Treatment of Recurrent or Persistant Platinum and Paclitaxel Refractory Ovarian or Primary Peritoneal Cancer.


 * GOG 126-E - Ovary - EVALUATION OF PACLITAXEL & SDZ PSC IN RECURRENT PLATINUM RESISTANT AND REFRACTORY OVARIAN CANCER


 * GOG 126-D - Ovary - EVALUATION OF PYRAZOLOACRIDINE (PZA) IN RECURRENT PLATINUM RESISTANT AND REFRACTORY OVARIAN CANCER


 * GOG 125 (1992-3) - Cervix - Phase II para-aortic RT with chemo
 * PMID 9869224 (1998)


 * GOG 123 (1992-97) - Cervix - A RANDOMIZED COMPARISON OF RT & ADJUVANT HYSTERECTOMY VS RT & WKLY CISPLATIN & ADJUVANT HYSTERECTOMY IN PATIENTS WITH BULKY STAGE IB CARCINOMA OF THE CERVIX
 * PMID 10202166, 1999


 * GOG 122 - Endometrium - Advanced Stage III-IV, randomized to whole abdominal XRT vs doxorubicin-cisplatin.
 * ASCO Abstract 2003 - "Whole abdominal radiotherapy versus combination doxorubicin-cisplatin chemotherapy in advanced endometrial carcinoma: A randomized phase III trial of the Gynecologic Oncology Group" Randall ME et al.


 * GOG 120 (1992-97) - Cervix - A RANDOMIZED COMPARISON OF HYDROXYUREA VERSUS HYDROXYUREA, 5-FU INFUSION AND BOLUS CISPLATIN VERSUS WEEKLY CISPLATIN AS ADJUNCT TO RADIATION THERAPY IN PATIENTS WITH STAGE IIB, III, IVA CARCINOMA OF THE CERVIX AND NEGATIVE PARA-AORTIC NODES
 * PMID 10202165 (1999, Full text)
 * PMID 19823064 (2009) - age 55+


 * GOG 117 - Uterus/Carcinosarcoma - Adjuvant Ifosfamide And Mesna With Cisplatin In Patient With Completely Resected Stage I Or II Mixed Mesodermal Tumors Of The Uterus (Phase I)


 * GOG 115 - Ovary/Stroma - BLEOMYCIN (NSC#125066), ETOPOSIDE(NSC#141540) AND CISPLATIN(NSC#119875)(BEP)AS 1ST-LINE THERAPY OF MALIGNANT TUMORS OF THE OVARIAN STROMA (GRANULOSA CELL, SERTOLI-LEYDIG TUMOR, AND UNCLASSIFIED SEX CORD STROMAL TUMOR)


 * GOG 110 - Cervix - A RANDOMIZED STUDY OF CISPLATIN VS CISPLATIN PLUS DIBROMODULCITOL VS CISPLATIN PLUS IFOSFAMIDE AND MESNA IN STAGE IVB, RECURRENT, PERSISTANT SQUAMOUS CELL CARCINOMA OF THE CERVIX


 * GOG 109 / Intergroup 0107 / SWOG 8797 / RTOG 91-12 (1991-96) - Cervix - A RANDOMIZED COMPARISON OF 5FU INFUSION + BOLUS CISPLATIN AS AN ADJUNCT TO RADIATION THERAPY, VS RADIATION ALONE IN SELECTED PATIENTS WITH STAGE 1-A2,1B,IIA, CARCINOMA OF THE CERVIX FOLLOWING RADICAL HYSTERECTOMY AND NODE DISSECTION
 * PMID 10764420 (2000)


 * GOG 108 - Uterus/Carcinosarcoma - A phase III trial of ifosfamide with or without cisplatin in carcinosarcoma of the uterus
 * PMID 11063636 (2000)


 * GOG 101 - Vulva - Preoperative chemo/RT for unresectable T3 or with bulky nodes.
 * PMID 9747823 (1998, for T3/T4), PMID 11072157 (2000, for bulky nodes)

51-100

 * GOG 95 - Ovary -A Randomized Clinical Trial For The Treatment Of Women With Selected Stage IC And II(A,B,C) And Selected Stage 1A And 1B Ovarian Cancer, Phase III.


 * GOG 94 (1986-94) - Endometrium - Phase II. Whole abdominal radiotherapy in the adjuvant treatment of patients with stage III and IV endometrial cancer. Also included Stage I-II papillary serous or clear cell.
 * PMID 15913742 (2005), PMID 16213007 (2005, papillary serous or clear cell)


 * GOG 92 (1988-95) - Cervix - Post-op, randomized to +/- RT. Risk factors.
 * Sedlis PMID 10329031 (1999), PMID 16427212 (2006)


 * GOG 88 (1991-1991) - Vulva - RT vs bilateral groin dissection.
 * PMID 1526880 (1992)


 * GOG 87-D - Uterus/Sarcoma - A PHASE II TRIAL OF VP-16 IN PATIENTS WITH ADVANCED UTERINE SARCOMA


 * GOG 87-B - Uterus/Sarcoma - A PHASE II TRIAL OF IFOSFAMIDE (NSC109724) AND THE UROPROTECTOR MESNA (NSC113891) IN THE TREATMENT OF RECURRENT OR ADVANCED UTERINE SARCOMAS


 * GOG 86-A - Endometrium - MASTER PROTOCOL FOR PHASE II DRUG STUDIES IN TREATMENT OF ADVANCED OR RECURRENT CARCINOMA OF THE ENDOMETRIUm


 * GOG 85 / SWOG 8695 (1986-90) - Cervix - RT + hydroxurea vs RT + cisplatin/5-FU
 * PMID 10334517 (1999)


 * GOG 81-A - Endometrium - MASTER PROTOCOL FOR HORMONAL TREATMENT OF ADVANCED OR RECURRENT CARCINOMA OF THE ENDOMETRIUM


 * GOG 74 - Vulva - Early Stage I Carcinoma of the Vulva Treated with Ipsilateral Superficial Inguinal Lymphadenectomy and Modified Radical Hemivulvectomy
 * PMID 19193428 (2009), PMID 8623839 (1996), PMID 1553164 (1992)


 * GOG 73 - Vulva Melanoma - Malignant melanoma of the vulva treated by radical hemivulvectomy
 * PMID 8174062 (1994)


 * GOG 71 / RTOG 84-12 (1984-91) - Cervix - TREATMENT OF PATIENTS WITH SUB-OPTIMAL (BULKY) STAGE 1B CARCINOMA OF THE CERVIX. A RANDOMIZED OF RADIATION THERAPY VS RADIATION PLUS ADJUVANT EXTRAFACIAL HYSTRECTOMY
 * PMID 12798694, 2003 - Keys


 * GOG 56 (1981-85) - Cervix - RT with Hydroxyurea vs misonidazole.
 * PMID 3293456 (preliminary report, 1988), PMID 8336190 (1993)
 * Effect of thrombocytosis: PMID 10926792 (2000)

1-50

 * GOG 49 (1981-84) - Cervix - Surgical staging.
 * PMID 2599466 (1989), PMID 2227547 (1990), PMID 1551060 (1992), PMID 1733218 (1992) - ovarian met


 * GOG 37 (1977-84) - Vulva - Pts with positive nodes (from GOG 36) randomized to pelvic LN dissection vs RT.
 * PMID 3785783 (1986), PMID 19701032 (2009)


 * GOG 36 (1977-84) - Vulva - Surgery-pathologic study after lymph node dissection.
 * PMID 8314530 (1993), PMID 2014852 (1991) - Staging, PMID 3578430 (1987)


 * GOG 34 - Endometrium - Surgery + RT +/- doxorubicin
 * PMID 2298404 (1990)


 * GOG 26-A - Other - MASTER PROTOCOL FOR PHASE II DRUG STUDIES IN TREATMENT OF ADVANCED, RECURRENT PELVIC MALIGNANCIES


 * GOG 20 (1973-1982) - Uterine sarcomas and carcinosarcoma - Adjuvant doxorubicin vs. no additional tx. Some patients got RT, and this decreased vaginal recurrence rate. But no effect on survival.
 * PMID 3897471 (1985)


 * GOG 19 (1973-6) - Cervix - Surgical staging.
 * PMID 7353805 (1980)


 * GOG 16 - Endometrium - Preop vs. Postop RT
 * Closed due to poor accrual


 * GOG 4 - Cervix - Hydroxyurea or Placebo Combined with Radiation to Treat Stage IIIB and IV Cervical Cancer Confined to the Pelvis.
 * PMID 1193437 (1975), PMID 110744 (1979)


 * GOG 3 - Ovary - Treatment for Women with Disseminated or Recurrent Advanced Ovarian Cancer with Melphalan Alone in Combination with 5-Fluorouracil and Dactinomycin
 * PMID 7378989 (1980),


 * GOG 2 - Ovary - Radiotherapy (RT), Chemotherapy (CT), and Combined Therapy in Stage III Epithelial Ovarian Cancer


 * GOG 1 - Ovary - The Role of Adjuvant Therapy in Stage I Ovarian Cancer
 * PMID 6252780 (1980), PMID 7078855 (No abstract) (1982)