Radiation Oncology/Cancer Syndromes/Ataxia-Telangiectasia-Like Disorder

Ataxia-Telangiectasia-Like Disorder


 * Online Mendelian Inheritance in Man Entry (Johns Hopkins)


 * Mutation in MRE11 (part of MRN complex)
 * Critical in recognition and repair of DNA double strand breaks
 * Cells are radiosensitive
 * Similar clinical features as Ataxia-Telangiectasia


 * Birmingham, UK; 2004 PMID 15279810 -- "Ataxia-telangiectasia-like disorder (ATLD)-its clinical presentation and molecular basis."(Taylor AM, DNA Repair (Amst). 2004 Aug-Sep;3(8-9):1219-25.)
 * Review