Radiation Oncology/CNS/Introduction

Survival
2-year and 5-year OS of various primary CNS tumors:
 * Astrocytoma, Pilocytic WHO grade I - 90%
 * Astrocytoma WHO grade II - 66%
 * Astrocytoma WHO grade III - 45% and 34%
 * GBM - 9%
 * Oligodendroglioma - 81% and 65%
 * Medulloblastoma - 66% and 60%
 * Ependymoma - 83% and 60%

Tumors that might be irradiated without pathologic diagnosis

 * Optic glioma
 * Diffuse pontine glioma
 * Meningioma
 * Choroidal melanoma

CNS tumors that are most likely to metastasize outside the CNS

 * Glioblastoma
 * Medulloblastoma
 * Ependymoma
 * Hemangiopericytoma
 * Meningioma

Pathologic correlations

 * Rosenthal fibers - JPA
 * Psammoma bodies - meningioma (and papillary tumors such as thyroid or endometrial)
 * Verocay bodies - schwannoma
 * Schiller Duval body - yolk sac tumor
 * Fried egg appearance - oligodendroglioma
 * Pseudorosettes (central lumen not formed by the growth itself, unlike a rosette) - ependymoma, but also PNET, medulloblastoma
 * Homer-Wright rosette - PNET, medulloblastoma, pineoblastoma, neuroblastoma
 * Flexner-Wintersteiner rosette - retinoblastoma