Radiation Oncology/CNS

Clinical Sections
Introduction

Adult:
 * Glioma
 * Meningioma
 * Primary CNS Lymphoma
 * Pineal Gland Tumors
 * Metastatic to brain
 * CSF involvement
 * Spine
 * Cerebral cavernous malformation
 * Miscellaneous CNS Tumors

Pediatric:
 * Craniopharyngioma
 * Glioma:
 * Optic Pathway Glioma
 * Brainstem Glioma
 * Pilocytic Astrocytoma
 * Germinoma
 * Ependymoma
 * Choroid Plexus Tumor
 * Medulloblastoma
 * CNS PNET
 * Pineal Gland tumors
 * Atypical Teratoid Rhabdoid Tumor (AT/RT)
 * Retinoblastoma

Benign:
 * Acoustic Neuroma (Vestibular Schwannoma)
 * Pituitary Adenoma
 * Trigeminal Neuralgia
 * Sphenopalatine Neuralgia
 * Chronic Cluster Headaches
 * Arteriovenous Malformation (AVM)
 * Cavernous Malformation
 * Hypothalamic Hamartoma
 * Glomus Jugulare (Paraganglioma)
 * Epilepsy
 * Cancer pain

See also:
 * Hemangiopericytoma

Proton therapy

CNS Toxicity:
 * Brain toxicity
 * Brainstem toxicity

RTOG Brain Trials

2007 WHO Classification
Neuroepithelial Tumors
 * Astrocytic Tumors
 * Pilocytic astrocytoma 9421/1
 * Pilomyxoid astrocytoma 9425/3
 * Subependymal giant cell astrocytoma 9384/1
 * Pleomorphic xanthoastrocytoma 9424/3
 * Diffuse astrocytoma 9400/3
 * Fibrillary astrocytoma 9420/3
 * Protoplasmic astrocytoma 9410/3
 * Gemistocytic astrocytoma 9411/3
 * Anaplastic astrocytoma 9401/3
 * Glioblastoma 9440/3
 * Giant cell glioblastoma 9441/3
 * Gliosarcoma 9442/3
 * Gliomatosis cerebri 9381/3


 * Oligodendroglial tumours
 * Oligodendroglioma 9450/3
 * Anaplastic oligodendroglioma 9451/3


 * Oligoastrocytic tumours
 * Oligoastrocytoma 9382/3
 * Anaplastic oligoastrocytoma 9382/3


 * Ependymal tumours
 * Subependymoma (WHO Grade 1) 9383/1
 * Myxopapillary ependymoma (WHO Grade 1) 9394/1
 * Ependymoma (WHO Grade 2) 9391/3
 * Cellular 9391/3
 * Papillary 9393/3
 * Clear cell 9391/3
 * Tanycytic 9391/3
 * Anaplastic ependymoma (WHO Grade 3) 9392/3


 * Choroid plexus tumours
 * Choroid plexus papilloma 9390/0
 * Atypical choroid plexus papilloma 9390/1*
 * Choroid plexus carcinoma 9390/3


 * Other neuroepithelial tumours
 * Astroblastoma 9430/3
 * Chordoid glioma of the third ventricle 9444/1
 * Angiocentric glioma 9431/1*


 * Neuronal and mixed neuronal-glial tumours
 * Dysplastic gangliocytoma of cerebellum (Lhermitte-Duclos) 9493/0
 * Desmoplastic infantile astrocytoma/ganglioglioma 9412/1
 * Dysembryoplastic neuroepithelial tumour 9413/0
 * Gangliocytoma 9492/0
 * Ganglioglioma 9505/1
 * Anaplastic ganglioglioma 9505/3
 * Papillary glioneuronal tumor 9509/1*
 * Rosette-forming glioneuronal tumour of the fourth ventricle 9509/1*
 * Central neurocytoma 9506/1
 * Extraventricular neurocytoma 9506/1*
 * Cerebellar liponeurocytoma 9506/1*
 * Paraganglioma of the filum terminale 8680/1

Tumours of the pineal region
 * Pineocytoma 9361/1
 * Pineal parenchymal tumour of intermediate differentiation 9362/3
 * Pineoblastoma 9362/3
 * Papillary tumour of the pineal region 9395/3*

Embryonal tumours
 * Medulloblastoma 9470/3
 * Desmoplastic/nodular medulloblastoma 9471/3
 * Medulloblastoma with extensive nodularity 9471/3*
 * Anaplastic medulloblastoma 9474/3*
 * Large cell medulloblastoma 9474/3
 * CNS primitive neuroectodermal tumours (PNETs)
 * CNS PNET, NOS 9473/3
 * CNS neuroblastoma 9500/3
 * CNS ganglioneuroblastoma 9490/3
 * Medulloepithelioma 9501/3
 * Ependymoblastoma 9392/3
 * Atypical teratoid / rhabdoid tumour 9508/3

Tumors of the Cranial and Paraspinal Nerves
 * Schwannoma (Neurilemoma, neurinoma) 9560/0
 * Cellular 9560/0
 * Plexiform 9560/0
 * Melanotic 9560/0
 * Neurofibroma 9540/0
 * Plexiform 9550/0
 * Perineurioma 9571/0
 * Intraneural perineurioma 9571/0
 * Soft tissue perineurioma 9571/0
 * Malignant peripheral nerve sheath tumour (MPNST) 9540/3
 * Epithelioid 9540/3
 * MPNST with divergent mesenchymal and / or epithelial differentiation 9540/3
 * Melanotic 9540/3

Tumors of the Meninges
 * Tumours of meningothelial cells
 * Meningioma 9530/0


 * Mesenchymal tumours
 * Lipoma 8850/0
 * Angiolipoma 8861/0
 * Hibernoma 8880/0
 * Liposarcoma (intracranial) 8850/3
 * Solitary fibrous tumour 8815/0
 * Fibrosarcoma 8810/3
 * Malignant fibrous histiocytoma 8830/3
 * Leiomyoma 8890/0
 * Leiomyosarcoma 8890/3
 * Rhabdomyoma 8900/0
 * Rhabdomyosarcoma 8900/3
 * Chondroma 9220/0
 * Chondrosarcoma 9220/3
 * Osteoma 9180/0
 * Osteosarcoma 9180/3
 * Osteochondroma 9210/0
 * Haemangioma 9120/0
 * Epithelioid haemangioendothelioma 9133/1
 * Haemangiopericytoma 9150/1
 * Angiosarcoma 9120/3
 * Kaposi sarcoma 9140/3


 * Primary melanocytic lesions
 * Diffuse melanocytosis 8728/0
 * Melanocytoma 8728/1
 * Malignant melanoma 8720/3
 * Meningeal melanomatosis 8728/3


 * Other neoplasms related to the meninges
 * Haemangioblastoma 9161/1

Lymphomas and Hematopoietic Neoplasms
 * Malignant lymphomas 9590/3
 * Plasmacytoma 9731/3
 * Granulocytic sarcoma 9930/3

Germ Cell Tumors
 * Germinoma 9064/3
 * Embryonal carcinoma 9070/3
 * Yolk sac tumour 9071/3
 * Choriocarcinoma 9100/3
 * Teratoma 9080/1
 * Mature 9080/0
 * Immature 9080/3
 * Teratoma with malignant transformation 9084/3
 * Mixed germ cell tumours 9085/3

Tumors of the Sellar Region
 * Craniopharyngioma 9350/1
 * Adamantinomatous 9351/1
 * Papillary 9352/1
 * Granular cell tumour 9582/0
 * Pituicytoma 9432/1*
 * Spindle cell oncocytoma of the adenohypophysis 8291/0*

Metastatic Tumors