Radiation Oncology/Bile duct/Randomized

Cholangiocarcinoma Randomized Evidence


 * Brno, Czech Republic (1994-?) -- stent +/- intraluminal brachytherapy
 * Randomized. 42 patients, obstruction, palliative intent. Arm 1) percutaneous self-expandable stent vs. Arm 2) stent + intraluminal BT Ir-192, mean 30 Gy over 4-5 days. Some also EBRT mean 50 Gy
 * 2007 PMID 17344008 -- "Brachytherapy and percutaneous stenting in the treatment of cholangiocarcinoma: a prospective randomised study." (Valek V, Eur J Radiol. 2007 May;62(2):175-9. Epub 2007 Mar 6.)
 * Outcome: Mean OS 10 months vs. 13 months (SS). Stent patency 8 months vs. 12 months
 * Conclusion: Addition of RT could extend survival of patients with cholangiocarcinoma obstruction