Radiation Oncology/Benign/PVNS

Pigmented Villonodular Synovitis


 * Rare proliferative disorder affecting joints, tendons, and bursae
 * Presnets as a nodule or a diffuse process of the synovium
 * Typically monoarticular
 * Young and middle-aged adults
 * Not clear whether it is a chronic inflammatory process or a neoplastic process
 * Work-up MRI, though presence of hemosiderin may overestimate size of lesion
 * Primary treatment is surgical resection, although complete resection may be difficult to obtain
 * Adjuvant therapy may include radioactive isotopes (Y90) or external beam RT
 * For EBRT, University of Florida review recommends 35 Gy in 14-15 fractions

Review
 * University of Florida; 2006 PMID 17148989 -- "Pigmented villonodular synovitis." (Mendenhall WM, Am J Clin Oncol. 2006 Dec;29(6):548-50.)