Gynecologic Oncology/Cervical Cancer

Chemotherapy for advanced and recurrent disease

 * Bonomi et al (GOG 43) PMID 3894589
 * Compared three regimens of cisplatin dosing
 * Regimen 1: 50 mg/m2 every 21 days
 * Regimen 2: 100 mg/m2 every 21 days
 * Regimen 3: 20 mg/m2 for five consecutive days repeated every 21 days
 * Differences in overall response rates were higher for regimen 2 (SS), but the PFS/OS/Complete response rates were virtually identical (NS)
 * Established 50 mg/m2 as the preferred regimen due to lower toxicity and ease (regimen 3 had multiple hospital visits)